This methylation profile is already acquired within the MBL stage3 and remains comparatively stable over time. Nonetheless, some CLL have intratumor variability in sure areas, which can alter the expression of a number of genes and facilitate tumor evolution.71 Of note, this variability is bigger in U-CLL than in M-CLL https://link-alternatif-mbl7780123.blogsumer.com/31652360/situs-judi-mbl77-no-further-a-mystery