Pentobarbital will minimize the extent or result of buprenorphine buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will lessen the level or outcome of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. pentobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 met... https://mariolegjm.actoblog.com/35557263/the-2-minute-rule-for-pentobarbital-for-cats